Anti-Inflammatory and Antioxidant Effects of Soroseris hirsuta Extract by Regulating iNOS/NF-κB and NRF2/HO-1 Pathways in Murine Macrophage RAW 264.7 Cells

Until now, the physiological effects of Soroseris hirsuta were primarily unknown. Here we have evaluated anti-inflammatory and antioxidant extract (SHE) on lipopolysaccharide (LPS)-activated murine macrophages RAW 264.7 cells. SHE inhibited nitric oxide expression inducible synthase in cells treated with LPS. Moreover, suppressed LPS-induced phosphorylation IκB kinase, inhibitor kappa B, p65, p38, c-JUN N-terminal kinase. Western blot immunofluorescence analyses showed that p65 nuclear translocation induced by Furthermore, reactive oxygen species LPS-treated significantly increased heme oxygenase-1 factor erythroid 2-related 2. interleukin-1β mRNA Thus, is a promising nutraceutical as it displays properties.